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The ability to target these pathways in a cell-specific manner may provide superior attenuation of fibrosis. A and B: Articles in Press. We have previously shown that primary AECs isolated from mouse lungs using the protocol described by Corti et al. Isolation of human serum spreading factor. Targeted injury of type II alveolar epithelial cells induces pulmonary fibrosis. Briefly, the lungs of euthanized mice were filled with dispase followed by low-melting-temperature agarose. After 5 days, mice were euthanized, and bronchoalveolar lavage BAL and lung samples were collected for analysis. Nat Rev Mol Cell Biol 6: Search for more papers by this author. Volume Issue We have further shown that the primary profibrotic effects of PAI-1 are mediated through its somatomedin B-binding domain rather than its function as a serine protease inhibitor 9. After germline transmission, mice were backcrossed into a C57BL6 background for at least ten generations. Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation.